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Year : 2018  |  Volume : 16  |  Issue : 4  |  Page : 155-157

Rifampicin-induced thrombocytopenia

Department of Medicine – Unit V, Christian Medical College, Vellore, Tamil Nadu, India

Correspondence Address:
Sultan Nawahirsha
Department of Medicine – Unit V, Christian Medical College, Vellore - 632 004, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cmi.cmi_7_19

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The discovery of rifampicin in 1965 ushered in the era of short-course antituberculosis (TB) chemotherapy. The duration of anti-TB therapy was reduced from 12–24 months to 6 months. Thrombocytopenia is an uncommon but severe side effect of rifampicin, which needs a high clinical index of suspicion for diagnosis. It reverses completely on stopping the drug. Re-challenge is not advised because thrombocytopenia will recur on re-initiation of the drug. We present the case of a patient with rifampicin-induced thrombocytopenia who presented with purpuric rash all over the body. Investigations revealed a low platelet count which resolved completely on stopping the drug. This case highlights the importance of diagnosis of a rare adverse drug reaction and prompts management, which leads to a good outcome.

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