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Year : 2020  |  Volume : 18  |  Issue : 3  |  Page : 184-188

Evaluation of nebulized lignocaine versus intravenous lignocaine for attenuation of pressor response to laryngoscopy and intubation

Department of Anaesthesiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India

Correspondence Address:
Dr. Priya Ganesan
Department of Anaesthesiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cmi.cmi_50_20

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Background: Laryngoscopy and intubation form an indispensable step in general anesthesia. They elicit significant sympathoadrenal responses. Suppression of these responses forms an essential step in general anesthesia. The aim of our study is to compare the efficacy of nebulized lidocaine versus intravenous (IV) lidocaine in suppressing the pressor response to laryngoscopy and intubation. Materials and Methods: One hundred patients within the age group of 18–65 years undergoing elective surgery under general anesthesia were randomly allocated into two groups: group IV lignocaine (IVL) (n = 50) and group nebulized lignocaine (NL) (n = 50). Baseline values of heart rate (HR), systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP), and saturation were noted. Patients received either nebulized or IV lidocaine according to the group. HR, saturation, BP, MAP, and arrhythmias were noted every minute from laryngoscopy up to 5 min postlaryngoscopy and intubation. Results: There was an increase in HR and BP from baseline in both the groups with laryngoscopy and intubation, and the increase is significantly less in NL (P < 0.05). The parameters in both the groups attained the baseline values at the 3rd min postintubation. However, the 4th- and 5th-min readings showed values below baseline in the nebulization group. Conclusion: This study suggests that NL may be more effective than IVL in suppressing pressor response to laryngoscopy and intubation.

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