Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2020  |  Volume : 18  |  Issue : 4  |  Page : 312-316

Choline-stabilized orthosilicic acid and bone health


Department of Orthopaedics, Mukund Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Ram Prabhoo
Mukund Nagar Co Operative Housing Society, J B Nagar, Andheri Kurla Road, Andheri East, Landmark, Near Marol Pipe Line, Mumbai - 400 059, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/cmi.cmi_78_20

Rights and Permissions

Certain trace elements play a very important role in bone health. Silicon is one such essential trace element required for bone regeneration, bone mineral density, and overall bone biology. Deficiency of silicon is associated with bone resorption rate, decreased osteoblastogenesis, increased osteoclastogenesis, reduced collagen, and glycosaminoglycan formation, suggesting a definite role of silicon in osteoporosis. Choline-stabilized orthosilicic acid (ch-OSA®) is a stable and bioavailable form of silicon. Due to its stable nature, it cannot be converted into nonabsorbable silica (polymerized) gel form. ch-OSA® is known to stimulate the enzymatic pathway of endogenous collagen synthesis. Silicon supplementation stimulates osteoblasts, osteoblastic differentiation, osteopontin, osteocalcin, alkaline phosphatase, and bone matrix mineralization. It inhibits bone resorption by reducing the surface area of osteoclasts. ch-OSA® has shown synergistic effects with calcium and Vitamin D, indicating its potential role in the management of osteoporosis. The aim of this review is to outline the importance of ch-OSA® on bone health.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed186    
    Printed6    
    Emailed0    
    PDF Downloaded19    
    Comments [Add]    

Recommend this journal