Current Medical Issues

: 2016  |  Volume : 14  |  Issue : 4  |  Page : 126--127

Is low sodium intake beneficial?

R Anand 
 Assistant Professor, Department of Biochemistry, Christian Medical College, Vellore, Tamil Nadu, India

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Anand R. Is low sodium intake beneficial?.Curr Med Issues 2016;14:126-127

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Anand R. Is low sodium intake beneficial?. Curr Med Issues [serial online] 2016 [cited 2021 Sep 25 ];14:126-127
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Several studies in the past have observed an association between dietary sodium (Na) intake and risk of cardiovascular disease (CVD) events and mortality. [1],[2],[3],[4] Interestingly, an increased risk of CVD is noted with both low and high Na intake states depicting a U-shaped profile. However, whether these observed associations are different between those with hypertension or without hypertension are not known.


Investigators of the present study recruited individuals who were part of four different cohorts, namely, PURE, DREAM, ONTARGET, and TRANSCEND. [5],[6],[7],[8] This included 133,118 individuals from 49 different countries. Among the study participants, 63,559 were hypertensives (HT Group) and 69,559 were without hypertension (non-HT Group). The study aimed at correlating dietary Na intake with the risk of cardiovascular events as their primary objective.

Since, an accurate, direct quantification of dietary Na intake is difficult, the researchers used an indirect approach. A morning fasting urine specimen was collected from all participants for estimation of spot Na. From the obtained value, a 24 h urine Na excretion was calculated using Kawasaki et al. formula. [9] This was used a surrogate marker for dietary Na intake. The 24 h urine excretion was correlated with the incidence of CVD events over 4 years.


The findings could be summarized in [Table 1]:{Table 1}

For each g change in intake of Na, the rise in systolic blood pressure was 2.08 mmHg in the HT group, while the rise was 1.22 mmHg in non-HT Group (P < 0.0001)In the HT Group, it was noted that high Na intake (>7 g/day) was associated with an increased risk of CVD in HT Group with a hazard ratio (HR) of 1·23 (95% confidence interval [CI] 1·11-1.37). On the other hand, low Na intake (<3 g/day) was also associated with an increased risk of CVD (HR 1·34 (95% CI 1·23-1·47)In the non-HT group, high Na intake was not associated with increased risk of CVD while low Na intake significantly increased the risk (HR 1·26 (95% CI 1·10-1·45)In both groups, moderate Na intake had no association with risk of CVD.Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.



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