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  Indian J Med Microbiol
 

Figure 1: The flow of traffic at 9 am (a) in front of Christian Medical College, Vellore hospital, resembles “traffic jam in the narrow lanes” in liver sinusoids/lung capillaries in secondary hemophagocytic lymphohistiocytosis while (b) normal traffic flow at 5 pm. In health, the lumen of lung capillaries and of liver sinusoids should contain 50% of blood cells and 50% of plasma; in secondary hemophagocytic lymphohistiocytosis, the lumen is drastically narrowed by hyperinflammation and leads to reduced organ perfusion and organ failure. Credits: Dr. Kirti Anna Koikkara.

Figure 1: The flow of traffic at 9 am (a) in front of Christian Medical College, Vellore hospital, resembles “traffic jam in the narrow lanes” in liver sinusoids/lung capillaries in secondary hemophagocytic lymphohistiocytosis while (b) normal traffic flow at 5 pm. In health, the lumen of lung capillaries and of liver sinusoids should contain 50% of blood cells and 50% of plasma; in secondary hemophagocytic lymphohistiocytosis, the lumen is drastically narrowed by hyperinflammation and leads to reduced organ perfusion and organ failure. Credits: Dr. Kirti Anna Koikkara.